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Leveraging Data Science to Elucidate Ligand Features for Pd-Catalyzed Enantioretentive N -Arylations of Cyclic α-Substituted Amines in Aqueous Media

https://doi.org/10.1021/jacs.5c07224

Ickes, Andrew R; Liles, Jordan P; Borlinghaus, Niginia; Henle, Jeremy; Swiatowiec, Rafal; Prakash_Kaushik, Niharika; Braje, Wilfried M; Harper, Kaid C; Shekhar, Shashank; Sigman, Matthew S (August 2025, Journal of the American Chemical Society)

Free, publicly-accessible full text available August 13, 2026
Stereoselective amino alcohol synthesis via chemoselective electrocatalytic radical cross-couplings

https://doi.org/10.1038/s41557-024-01695-7

Sun, Jiawei; Wang, Shuanghu; Harper, Kaid C; Kawamata, Yu; Baran, Phil S (January 2025, Nature Chemistry)

Free, publicly-accessible full text available January 3, 2026
Overcoming the limitations of Kolbe coupling with waveform-controlled electrosynthesis

https://doi.org/10.1126/science.adf4762

Hioki, Yuta; Costantini, Matteo; Griffin, Jeremy; Harper, Kaid C.; Merini, Melania Prado; Nissl, Benedikt; Kawamata, Yu; Baran, Phil S. (April 2023, Science)

Rapid alternating polarity greatly expands the functional compatibility of a venerable electrochemical carbon–carbon coupling.
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Chemoselective (Hetero)Arene Electroreduction Enabled by Rapid Alternating Polarity

https://doi.org/10.1021/jacs.2c02102

Hayashi, Kyohei; Griffin, Jeremy; Harper, Kaid C.; Kawamata, Yu; Baran, Phil S. (March 2022, Journal of the American Chemical Society)

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Continuous Process to Safely Manufacture an Aryldiazoacetate and Its Direct Use in a Dirhodium-Catalyzed Enantioselective Cyclopropanation

https://doi.org/10.1021/acs.oprd.2c00288

Lathrop, Stephen P.; Mlinar, Laurie B.; Manjrekar, Onkar N.; Zhou, Yong; Harper, Kaid C.; Sacia, Eric R.; Higgins, Molly; Bogdan, Andrew R.; Wang, Zhe; Richter, Steven M.; et al (January 2023, Organic Process Research & Development)

Full Text Available
Scalable Electrochemical Decarboxylative Olefination Driven by Alternating Polarity**

https://doi.org/10.1002/anie.202309157

Garrido‐Castro, Alberto F.; Hioki, Yuta; Kusumoto, Yoshifumi; Hayashi, Kyohei; Griffin, Jeremy; Harper, Kaid C.; Kawamata, Yu; Baran, Phil S. (September 2023, Angewandte Chemie International Edition)

Abstract A mild, scalable (kg) metal‐free electrochemical decarboxylation of alkyl carboxylic acids to olefins is disclosed. Numerous applications are presented wherein this transformation can simplify alkene synthesis and provide alternative synthetic access to valuable olefins from simple carboxylic acid feedstocks. This robust method relies on alternating polarity to maintain the quality of the electrode surface and local pH, providing a deeper understanding of the Hofer‐Moest process with unprecedented chemoselectivity.
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